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Mouse Anti-SPIB Recombinant Antibody (CBXS-2464) (CBMAB-S5221-CQ)

This product is a mouse antibody that recognizes SPIB. The antibody CBXS-2464 can be used for immunoassay techniques such as: ELISA, FC, ICC, IHC, WB.
See all SPIB antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBXS-2464
Antibody Isotype
IgG1
Application
ELISA, FC, ICC, IHC, WB

Basic Information

Immunogen
Purified recombinant fragment of human SPIB (aa 200-252)
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascites fluid
Preservative
0.03% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Spi-B Transcription Factor
Introduction
The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human6689
Mouse272382
UniProt ID
HumanQ01892
MouseO35906
Alternative Names
Spi-B Transcription Factor; Spi-B Transcription Factor (Spi-1/PU.1 Related); Transcription Factor Spi-B; SPI-B;
Function
Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.
Biological Process
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:NTNU_SB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 1
Nucleus
Isoform 2
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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