SPIB

The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Full Name
Spi-B Transcription Factor
Function
Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.
Biological Process
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:NTNU_SB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 1
Nucleus
Isoform 2
Cytoplasm
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Anti-SPIB antibodies

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Mouse Anti-SPIB Recombinant Antibody (CBT3332) (V2LY-0625-LY2824)

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Target: SPIB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT3332
Application*: WB, IH, IC, F
Datasheet SDS

Rabbit Anti-SPIB Recombinant Antibody (D3C5E) (CBMAB-CP2554-LY)

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Target: SPIB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D3C5E
Application*: IP, IF (IC), F
Datasheet SDS

Mouse Anti-SPIB Recombinant Antibody (CBXS-2464) (CBMAB-S5221-CQ)

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Target: SPIB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXS-2464
Application*: E, F, IC, IH, WB
Datasheet SDS

Mouse Anti-SPIB Recombinant Antibody (CBXS-1934) (CBMAB-S4717-CQ)

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Target: SPIB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1934
Application*: WB
Datasheet SDS

Rabbit Anti-SPIB Recombinant Antibody (CBXS-5403) (CBMAB-S2615-CQ)

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Target: SPIB
Host: Rabbit
Specificity: Human, Mouse
Clone: CBXS-5403
Application*: WB, IP
Datasheet SDS

Rabbit Anti-SPIB Recombinant Antibody (CBXS-5380) (CBMAB-S2593-CQ)

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Target: SPIB
Host: Rabbit
Specificity: Human
Clone: CBXS-5380
Application*: IP, IF, F
Datasheet SDS

Mouse Anti-SPIB Recombinant Antibody (CBXS-5088) (CBMAB-S2308-CQ)

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Target: SPIB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXS-5088
Application*: F, IC, IF, IH, WB
Datasheet SDS

Mouse Anti-SPIB Recombinant Antibody (CBXS-4278) (CBMAB-S1526-CQ)

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Target: SPIB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4278
Application*: IC, IF, P, WB
Datasheet SDS

Mouse Anti-SPIB Recombinant Antibody (CBXS-5699) (CBMAB-S0567-CQ)

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Target: SPIB
Host: Mouse
Specificity: Mouse, Human
Clone: CBXS-5699
Application*: WB, IP, IF, F, E
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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