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Mouse Anti-SPIC Monoclonal Antibody (1F10) (CBMAB-0178-LY)

This product is mouse monoclonal antibody recognizes SPIC of human. The antibody 1F10 immunoassay techniques such as: IP, MA.
See all SPIC antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F10
Antibody Isotype
IgG2b
Application
IP, MA

Basic Information

Immunogen
Recombinant peptide (Full Length)
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Spi-C Transcription Factor
Introduction
The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. This protein controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. As a transcription factor, the protein binds to the PU-box. The gene is a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Also, it regulates VCAM1 gene expression.
Entrez Gene ID
121599
UniProt ID
Q8N5J4
Alternative Names
MGC40611; SPI-C
Function
Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).
Biological Process
Biological Process blastocyst developmentIEA:Ensembl
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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