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SPIC

The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells.

Full Name

Spi-C Transcription Factor

Function

Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).

Biological Process

Biological Process blastocyst developmentIEA:Ensembl
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

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Anti-SPIC antibodies

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Mouse Anti-SPIC Monoclonal Antibody (2C5) (CBMAB-0180-LY)

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Target: SPIC

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2C5

Application*: IP, M

Mouse Anti-SPIC Recombinant Antibody (CBXS-2091) (CBMAB-S4856-CQ)

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Target: SPIC

Host: Mouse

Specificity: Human

Clone: CBXS-2091

Application*: WB, IP, IF, E

Mouse Anti-SPIC Monoclonal Antibody (2C11) (CBMAB-0179-LY)

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Target: SPIC

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2C11

Application*: IP, M

Mouse Anti-SPIC Monoclonal Antibody (1F10) (CBMAB-0178-LY)

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Target: SPIC

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1F10

Application*: IP, M

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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