SPIC

The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells.

Full Name

Spi-C Transcription Factor

Function

Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity).

Biological Process

Biological Process blastocyst developmentIEA:Ensembl
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Anti-SPIC antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-SPIC Recombinant Antibody (CBXS-2091) (CBMAB-S4856-CQ)

Datasheet

SDS

Target: SPIC

Host: Mouse

Specificity: Human

Clone: CBXS-2091

Application*: WB, IP, IF, E

Mouse Anti-SPIC Monoclonal Antibody (2C5) (CBMAB-0180-LY)

Datasheet

SDS

Target: SPIC

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2C5

Application*: IP, M

Mouse Anti-SPIC Monoclonal Antibody (2C11) (CBMAB-0179-LY)

Datasheet

SDS

Target: SPIC

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2C11

Application*: IP, M

Mouse Anti-SPIC Monoclonal Antibody (1F10) (CBMAB-0178-LY)

Datasheet

SDS

Target: SPIC

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1F10

Application*: IP, M

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)