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Mouse Anti-SPP1 Antibody (MPIIIB10(1)) (CBMAB-0878-YC)

Provided herein are mouse monoclonal antibodies against Rat SPP1. The antibody clone MPIIIB10(1) can be used for immunoassay techniques, such as IF, IF-cells and IHC.
See all SPP1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Human, Rabbit, Mouse
Clone
MPIIIB10(1)
Antibody Isotype
IgG1
Application
IF, IF-cells and IHC

Basic Information

Specificity
Rat, Human, Rabbit, Mouse
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Secreted Phosphoprotein 1
Introduction
SPP1 (Osteopontin) is involved in the attachment of osteoclasts to the mineralized bone matrix. SPP1 is secreted and binds hydroxyapatite with high affinity. SPP1 is also a cytokine that upregulates expression of interferon-gamma and interleukin-12.
Entrez Gene ID
Human6696
Mouse20750
Rat25353
Rabbit100008982
UniProt ID
HumanP10451
MouseP10923
RatP08721
RabbitP31097
Alternative Names
OPN; BNSP; BSPI; ETA-1; Osteopontin
Function
Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
Biological Process
Biological Process androgen catabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process biomineral tissue developmentIEA:UniProtKB-KW
Biological Process cell adhesionManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process cellular response to testosterone stimulusManual Assertion Based On ExperimentIDA:CAFA
Biological Process decidualizationManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process embryo implantationManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process inflammatory responseIEA:Ensembl
Biological Process negative regulation of collateral sprouting of intact axon in response to injuryIEA:Ensembl
Biological Process osteoblast differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of bone resorptionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIDA:CAFA
Biological Process positive regulation of estradiol secretionManual Assertion Based On ExperimentIDA:CAFA
Biological Process response to macrophage colony-stimulating factorIEA:Ensembl
Biological Process response to steroid hormoneIEA:Ensembl
Biological Process response to vitamin DManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Secreted
PTM
Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers, increasing its collagen binding properties.
Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif (PubMed:15869464, PubMed:22582013, PubMed:26091039).
The phosphorylated form inhibits hydroxyapatite crystallization. Dephosphorylation via a mechanism involving ALPL/TNAP promotes hydroxyapatite crystallization (By similarity).
O-glycosylated. Isoform 5 is GalNAc O-glycosylated at Thr-59 or Ser-62.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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