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Mouse Anti-SPPL2A Recombinant Antibody (1C7) (CBMAB-A8566-LY)

The product is antibody recognizes SPPL2A. The antibody 1C7 immunoassay techniques such as: WB, ELISA.
See all SPPL2A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C7
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
SPPL2A (NP_116191.2, 31 a.a. ~ 129 a.a) partial recombinant protein with GST-pstS1 tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
signal peptide peptidase-like 2A
Introduction
This gene is a member of the signal peptide peptidase-like protease (SPPL) family and encodes an endosomal membrane protein with a protease associated (PA) domain. This protein plays a role in innate and adaptive immunity. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq]
Entrez Gene ID
84888
UniProt ID
Q8TCT8
Alternative Names
IMP3; PSL2
Function
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014).
Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952).
Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115).
Essential for degradation of the invariant chain CD74 that plays a central role in the function of antigen-presenting cells in the immune system (By similarity).
Plays a role in the regulation of innate and adaptive immunity (PubMed:16829952).
Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).
Biological Process
Biological Process membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process membrane protein intracellular domain proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process membrane protein proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of tumor necrosis factor-mediated signaling pathwayTAS:Reactome
Cellular Location
Late endosome membrane
Lysosome membrane
Membrane
Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane.
Involvement in disease
Immunodeficiency 86 (IMD86):
An autosomal recessive disorder characterized by susceptibility to mycobacterial disease after exposure to BCG vaccine. Affected individuals usually develop localized mycobacterial lymphadenopathy.
Topology
Lumenal: 26-172
Helical: 173-193
Cytoplasmic: 194-220
Helical: 221-241
Lumenal: 242-247
Helical: 248-268
Cytoplasmic: 269-285
Helical: 286-306
Lumenal: 307-311
Helical: 312-332
Cytoplasmic: 333-340
Helical: 341-361
Lumenal: 362-399
Helical: 400-420
Cytoplasmic: 421-437
Helical: 438-458
Lumenal: 459-460
Helical: 461-481
Cytoplasmic: 482-520
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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