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Mouse Anti-SPPL2A Recombinant Antibody (CBXS-3939) (CBMAB-S1203-CQ)

This product is a mouse antibody that recognizes SPPL2A. The antibody CBXS-3939 can be used for immunoassay techniques such as: WB, IP, ELISA.
See all SPPL2A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3939
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
signal peptide peptidase-like 2A
Introduction
This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15.
Entrez Gene ID
84888
UniProt ID
Q8TCT8
Alternative Names
Signal Peptide Peptidase Like 2A; Presenilin-Like Protein 2; Intramembrane Protease 3; SPP-Like 2A; IMP-3; IMP3;
Function
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014).
Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952).
Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115).
Essential for degradation of the invariant chain CD74 that plays a central role in the function of antigen-presenting cells in the immune system (By similarity).
Plays a role in the regulation of innate and adaptive immunity (PubMed:16829952).
Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).
Biological Process
Biological Process membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process membrane protein intracellular domain proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process membrane protein proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of tumor necrosis factor-mediated signaling pathwayTAS:Reactome
Cellular Location
Late endosome membrane
Lysosome membrane
Membrane
Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane.
Involvement in disease
Immunodeficiency 86 (IMD86):
An autosomal recessive disorder characterized by susceptibility to mycobacterial disease after exposure to BCG vaccine. Affected individuals usually develop localized mycobacterial lymphadenopathy.
Topology
Lumenal: 26-172
Helical: 173-193
Cytoplasmic: 194-220
Helical: 221-241
Lumenal: 242-247
Helical: 248-268
Cytoplasmic: 269-285
Helical: 286-306
Lumenal: 307-311
Helical: 312-332
Cytoplasmic: 333-340
Helical: 341-361
Lumenal: 362-399
Helical: 400-420
Cytoplasmic: 421-437
Helical: 438-458
Lumenal: 459-460
Helical: 461-481
Cytoplasmic: 482-520
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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