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Mouse Anti-SPRED1 Recombinant Antibody (CBXS-5654) (CBMAB-S0259-CQ)

This product is a mouse antibody that recognizes SPRED1. The antibody CBXS-5654 can be used for immunoassay techniques such as: ELISA, WB.
See all SPRED1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5654
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sprouty Related EVH1 Domain Containing 1
Introduction
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).
Entrez Gene ID
161742
UniProt ID
Q7Z699
Alternative Names
Sprouty Related EVH1 Domain Containing 1; Protein Phosphatase 1, Regulatory Subunit 147; Spred-1; HSpred1; Sprouty-Related, EVH1 Domain-Containing Protein 1; Suppressor Of Ras/MAPK Activation; PPP1R147; NFLS;
Function
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity).
Negatively regulates hematopoiesis of bone marrow (By similarity).
Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity).
Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281).
Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
Biological Process
Biological Process negative regulation of angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of cell migration involved in sprouting angiogenesisIEA:Ensembl
Biological Process negative regulation of epithelial to mesenchymal transitionISS:UniProtKB
Biological Process negative regulation of ERK1 and ERK2 cascadeISS:UniProtKB
Biological Process negative regulation of lens fiber cell differentiationISS:UniProtKB
Biological Process negative regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of peptidyl-threonine phosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of protein kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwayISS:UniProtKB
Biological Process positive regulation of DNA damage response, signal transduction by p53 class mediatorBy SimilarityISS:BHF-UCL
Biological Process regulation of MAPK cascadeManual Assertion Based On ExperimentTAS:ARUK-UCL
Biological Process regulation of protein deacetylationBy SimilarityISS:BHF-UCL
Biological Process vasculogenesis involved in coronary vascular morphogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Cell membrane
Membrane, caveola
Nucleus
Localized in cholesterol-rich membrane raft/caveola fractions.
Involvement in disease
Legius syndrome (LGSS):
An autosomal dominant syndrome characterized mainly by cafe-au-lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities, and features of attention-deficit hyperactivity disorder.
PTM
Palmitoylated by ZDHHC17/HIP14.
Phosphorylated on tyrosine.
Ubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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