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Mouse Anti-SPRR2A Recombinant Antibody (CBXS-4985) (CBMAB-S2207-CQ)

This product is a mouse antibody that recognizes SPRR2A. The antibody CBXS-4985 can be used for immunoassay techniques such as: WB.
See all SPRR2A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4985
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant full length human SPRR2A (NP_005979)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Small Proline Rich Protein 2A
Introduction
SPRR2A (Small Proline Rich Protein 2A) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. An important paralog of this gene is SPRR2B.
Entrez Gene ID
6700
UniProt ID
P35326
Alternative Names
Small Proline Rich Protein 2A; Small Proline-Rich Protein 2A; SPR-2A; 2-1;
Function
Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226).
Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (PubMed:34735226).
Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (By similarity).
May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (PubMed:8325635).
Biological Process
Biological Process antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process host-mediated regulation of intestinal microbiota compositionISS:UniProtKB
Cellular Location
Secreted
Secreted, extracellular space
Cytoplasmic vesicle, secretory vesicle
Present in intestinal secretory epithelial cells and is secreted into the intestinal lumen.
PTM
Forms five pairs of intrachain disulfide bonds.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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