Mouse Anti-SPRR2A Recombinant Antibody (CBXS-4985) (CBMAB-S2207-CQ)

Name: Mouse Anti-SPRR2A Recombinant Antibody (CBXS-4985)
SKU: CBMAB-S2207-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-4985

Application

Immunogen

Recombinant full length human SPRR2A (NP_005979)

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Small Proline Rich Protein 2A

Introduction

SPRR2A (Small Proline Rich Protein 2A) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. An important paralog of this gene is SPRR2B.

Entrez Gene ID

6700

UniProt ID

P35326

Alternative Names

Small Proline Rich Protein 2A; Small Proline-Rich Protein 2A; SPR-2A; 2-1;

Function

Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226).
Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (PubMed:34735226).
Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (By similarity).
May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (PubMed:8325635).

Biological Process

Biological Process antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process host-mediated regulation of intestinal microbiota compositionISS:UniProtKB

Cellular Location

Secreted
Secreted, extracellular space
Cytoplasmic vesicle, secretory vesicle
Present in intestinal secretory epithelial cells and is secreted into the intestinal lumen.

PTM

Forms five pairs of intrachain disulfide bonds.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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