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Mouse Anti-SPTA1 Recombinant Antibody (CBXS-3767) (CBMAB-S1039-CQ)

This product is a mouse antibody that recognizes SPTA1. The antibody CBXS-3767 can be used for immunoassay techniques such as: ELISA, ICC, IF, IHC-Fr, WB.
See all SPTA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXS-3767
Antibody Isotype
IgG1
Application
ELISA, ICC, IF, IHC-Fr, WB

Basic Information

Immunogen
Recombinant alpha I spectrin (erythroid spectrin) SH3 domain
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Spectrin Alpha, Erythrocytic 1
Introduction
This gene encodes a member of a family of molecular scaffold proteins that link the plasma membrane to the actin cytoskeleton and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms a component of the erythrocyte plasma membrane. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis-2, pyropoikilocytosis, and spherocytosis, type 3.
Entrez Gene ID
Human6708
Mouse20739
Rat289257
UniProt ID
HumanP02549
MouseP08032
RatD4A678
Alternative Names
Spectrin Alpha, Erythrocytic 1; Erythroid Alpha-Spectrin; Elliptocytosis 2; SPTA; Spectrin, Alpha, Erythrocytic 1 (Elliptocytosis 2); Spectrin Alpha Chain, Erythrocytic 1; Spectrin Alpha Chain, Erythrocyte;
Function
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
Biological Process
Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process actin filament cappingIEA:UniProtKB-KW
Biological Process actin filament organizationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process hemopoiesisIEA:Ensembl
Biological Process lymphocyte homeostasisIEA:Ensembl
Biological Process plasma membrane organizationIEA:Ensembl
Biological Process porphyrin-containing compound biosynthetic processIEA:Ensembl
Biological Process positive regulation of protein bindingIEA:Ensembl
Biological Process positive regulation of T cell proliferationIEA:Ensembl
Biological Process regulation of cell shapeIEA:UniProtKB-KW
Cellular Location
Cytoplasm, cytoskeleton
Cytoplasm, cell cortex
Involvement in disease
Elliptocytosis 2 (EL2):
A Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
Hereditary pyropoikilocytosis (HPP):
Autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.
Spherocytosis 3 (SPH3):
Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH3 is characterized by severe hemolytic anemia. Inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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