Mouse Anti-SPTA1 Recombinant Antibody (Spe 1/2) (CBMAB-S6604-CQ)

Name: Mouse Anti-SPTA1 Recombinant Antibody (Spe 1/2)
SKU: CBMAB-S6604-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

Spe 1/2

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 2% BSA

Preservative

0.09% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Spectrin Alpha, Erythrocytic 1

Introduction

This gene encodes a member of a family of molecular scaffold proteins that link the plasma membrane to the actin cytoskeleton and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms a component of the erythrocyte plasma membrane. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis-2, pyropoikilocytosis, and spherocytosis, type 3.

Entrez Gene ID

6708

UniProt ID

P02549

Alternative Names

Spectrin Alpha, Erythrocytic 1; Erythroid Alpha-Spectrin; Elliptocytosis 2; SPTA; Spectrin, Alpha, Erythrocytic 1 (Elliptocytosis 2); Spectrin Alpha Chain, Erythrocytic 1; Spectrin Alpha Chain, Erythrocyte;

Function

Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.

Biological Process

Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process actin filament cappingIEA:UniProtKB-KW
Biological Process actin filament organizationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process hemopoiesisIEA:Ensembl
Biological Process lymphocyte homeostasisIEA:Ensembl
Biological Process plasma membrane organizationIEA:Ensembl
Biological Process porphyrin-containing compound biosynthetic processIEA:Ensembl
Biological Process positive regulation of protein bindingIEA:Ensembl
Biological Process positive regulation of T cell proliferationIEA:Ensembl
Biological Process regulation of cell shapeIEA:UniProtKB-KW

Cellular Location

Cytoplasm, cytoskeleton
Cytoplasm, cell cortex

Involvement in disease

Elliptocytosis 2 (EL2):
A Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
Hereditary pyropoikilocytosis (HPP):
Autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.
Spherocytosis 3 (SPH3):
Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH3 is characterized by severe hemolytic anemia. Inheritance is autosomal recessive.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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