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Rabbit Anti-SPTBN1 Recombinant Antibody (CBXS-1536) (CBMAB-S4386-CQ)

This product is a rabbit antibody that recognizes SPTBN1. The antibody CBXS-1536 can be used for immunoassay techniques such as: WB, IHC-P, ICC.
See all SPTBN1 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1536
Antibody Isotype
IgG
Application
WB, IHC-P, ICC

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Spectrin Beta, Non-Erythrocytic 1
Introduction
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human6711
Mouse20742
Rat305614
UniProt ID
HumanQ01082
MouseQ62261
RatP16086
Alternative Names
Spectrin Beta, Non-Erythrocytic 1; Fodrin Beta Chain; Beta-II Spectrin; Spectrin, Non-Erythroid Beta Chain 1; SPTB2; Spectrin Beta Chain, Non-Erythrocytic 1; Beta-Spectrin Non-Erythrocytic 1; Epididymis Luminal Protein 102; Spectrin Beta Chain, Brain 1;
Function
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function.
Biological Process
Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process actin filament cappingIEA:UniProtKB-KW
Biological Process central nervous system developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process central nervous system formationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process common-partner SMAD protein phosphorylationIEA:Ensembl
Biological Process Golgi to plasma membrane protein transportManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process membrane assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process plasma membrane organizationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of interleukin-2 productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process regulation of SMAD protein signal transductionIEA:Ensembl
Cellular Location
Cytoplasm, cytoskeleton
Cytoplasm, myofibril, sarcomere, M line
Cytoplasm, cytosol
Cell membrane
Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes.
Isoform 2
Cell membrane
Involvement in disease
Developmental delay, impaired speech, and behavioral abnormalities (DDISBA):
An autosomal dominant disorder characterized by developmental delay with speech impairment, mild to severe intellectual disability, and behavioral abnormalities including autistic features. Additional variable manifestations may include dysmorphic facial features, seizures, hypotonia, motor abnormalities, and hearing loss.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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