Mouse Anti-SPTBN1 Recombinant Antibody (CBXS-2227) (CBMAB-S4989-CQ)

Name: Mouse Anti-SPTBN1 Recombinant Antibody (CBXS-2227)
SKU: CBMAB-S4989-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBXS-2227

Application

WB, IP, IF, ELISA

Specificity

Mouse, Rat, Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Spectrin Beta, Non-Erythrocytic 1

Introduction

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

Human	6711
Mouse	20742
Rat	305614

UniProt ID

Human	Q01082
Mouse	Q62261
Rat	P16086

Alternative Names

Spectrin Beta, Non-Erythrocytic 1; Fodrin Beta Chain; Beta-II Spectrin; Spectrin, Non-Erythroid Beta Chain 1; SPTB2; Spectrin Beta Chain, Non-Erythrocytic 1; Beta-Spectrin Non-Erythrocytic 1; Epididymis Luminal Protein 102; Spectrin Beta Chain, Brain 1;

Function

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function.

Biological Process

Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process actin filament cappingIEA:UniProtKB-KW
Biological Process central nervous system developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process central nervous system formationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process common-partner SMAD protein phosphorylationIEA:Ensembl
Biological Process Golgi to plasma membrane protein transportManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process membrane assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process plasma membrane organizationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of interleukin-2 productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process regulation of SMAD protein signal transductionIEA:Ensembl

Cellular Location

Cytoplasm, cytoskeleton
Cytoplasm, myofibril, sarcomere, M line
Cytoplasm, cytosol
Cell membrane
Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes.
Isoform 2
Cell membrane

Involvement in disease

Developmental delay, impaired speech, and behavioral abnormalities (DDISBA):
An autosomal dominant disorder characterized by developmental delay with speech impairment, mild to severe intellectual disability, and behavioral abnormalities including autistic features. Additional variable manifestations may include dysmorphic facial features, seizures, hypotonia, motor abnormalities, and hearing loss.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-SPTBN1 Recombinant Antibody (CBXS-1536) (CAT#: CBMAB-S4386-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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