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Rabbit Anti-SRD5A2 Recombinant Antibody (CBXS-1542) (CBMAB-S4391-CQ)

This product is a rabbit antibody that recognizes SRD5A2. The antibody CBXS-1542 can be used for immunoassay techniques such as: WB, IP.
See all SRD5A2 antibodies

Summary

Host Animal
Rabbit
Specificity
Rat, Human
Clone
CBXS-1542
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Introduction
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
Entrez Gene ID
Human6716
Rat64677
UniProt ID
HumanP31213
RatP31214
Alternative Names
Steroid 5 Alpha-Reductase 2; Steroid-5-Alpha-Reductase, Alpha Polypeptide 2 (3-Oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 2); 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2; Steroid 5-Alpha-Reductase 2; Type II 5-Alpha Reductase; 5 Alpha-SR2; EC 1.3.1.22; SR Type 2; S5AR 2;
Function
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Biological Process
Biological Process androgen biosynthetic processTAS:Reactome
Biological Process androgen metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process biphenyl metabolic processIEA:Ensembl
Biological Process bone developmentIEA:Ensembl
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cell-cell signalingManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process dibenzo-p-dioxin metabolic processIEA:Ensembl
Biological Process female genitalia developmentIEA:Ensembl
Biological Process hippocampus developmentIEA:Ensembl
Biological Process hypothalamus developmentIEA:Ensembl
Biological Process male genitalia developmentIEA:Ensembl
Biological Process male gonad developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process phthalate metabolic processIEA:Ensembl
Biological Process response to follicle-stimulating hormoneIEA:Ensembl
Biological Process response to nutrient levelsIEA:Ensembl
Biological Process response to peptide hormoneIEA:Ensembl
Biological Process response to steroid hormoneIEA:Ensembl
Biological Process response to testosteroneIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process steroid biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process steroid catabolic processIEA:Ensembl
Biological Process testosterone biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Microsome membrane
Endoplasmic reticulum membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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