SRD5A2

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq]

Full Name

steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)

Function

Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Biological Process

Biological Process androgen biosynthetic processTAS:Reactome
Biological Process androgen metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process biphenyl metabolic processIEA:Ensembl
Biological Process bone developmentIEA:Ensembl
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cell-cell signalingManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process dibenzo-p-dioxin metabolic processIEA:Ensembl
Biological Process female genitalia developmentIEA:Ensembl
Biological Process hippocampus developmentIEA:Ensembl
Biological Process hypothalamus developmentIEA:Ensembl
Biological Process male genitalia developmentIEA:Ensembl
Biological Process male gonad developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process phthalate metabolic processIEA:Ensembl
Biological Process response to follicle-stimulating hormoneIEA:Ensembl
Biological Process response to nutrient levelsIEA:Ensembl
Biological Process response to peptide hormoneIEA:Ensembl
Biological Process response to steroid hormoneIEA:Ensembl
Biological Process response to testosteroneIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process steroid biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process steroid catabolic processIEA:Ensembl
Biological Process testosterone biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Microsome membrane
Endoplasmic reticulum membrane