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Mouse Anti-SRP68 Recombinant Antibody (3A3) (CBMAB-A8598-LY)

The product is antibody recognizes SRP68. The antibody 3A3 immunoassay techniques such as: WB, ELISA.
See all SRP68 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A3
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SRP68 (NP_055045.2, 531 a.a. ~ 627 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
signal recognition particle 68kDa
Introduction
The signal recognition particle (SRP) is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. This gene encodes the 68kDa component of the SRP. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq]
Entrez Gene ID
6730
UniProt ID
Q9UHB9
Function
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957).
The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957).
The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957).
Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (PubMed:16672232, PubMed:27899666).
The SRP complex possibly participates in the elongation arrest function (By similarity).
Biological Process
Biological Process response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process SRP-dependent cotranslational protein targeting to membraneIEA:InterPro
Cellular Location
Cytoplasm
Nucleus, nucleolus
Endoplasmic reticulum
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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