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Mouse Anti-SRP68 Recombinant Antibody (CBXS-4736) (CBMAB-S1965-CQ)

This product is a mouse antibody that recognizes SRP68. The antibody CBXS-4736 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all SRP68 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4736
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
signal recognition particle 68kDa
Introduction
This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17.
Entrez Gene ID
6730
UniProt ID
Q9UHB9
Alternative Names
Signal Recognition Particle 68; Signal Recognition Particle 68 KDa Protein; Signal Recognition Particle 68kDa; Signal Recognition Particle 68kD;
Function
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957).
The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957).
The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957).
Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (PubMed:16672232, PubMed:27899666).
The SRP complex possibly participates in the elongation arrest function (By similarity).
Biological Process
Biological Process response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process SRP-dependent cotranslational protein targeting to membraneIEA:InterPro
Cellular Location
Cytoplasm
Nucleus, nucleolus
Endoplasmic reticulum
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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