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Recombinant Mouse Anti-SRSF7 Recombinant Antibody (2G8-1C6) (CBMAB-XB1068-YC)

Provided herein is a Mouse Recombinant Antibody against Serine And Arginine Rich Splicing Factor 7. The antibody can be used for immunoassay techniques, such as IF, WB.
See all SRSF7 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
2G8-1C6
Antibody Isotype
IgG1, κ
Application
IF, WB

Basic Information

Immunogen
MSRYGRYGGETK(C)
Specificity
Human, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serine And Arginine Rich Splicing Factor 7
Introduction
SRSF7 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation.
Entrez Gene ID
Human6432
Mouse225027
UniProt ID
HumanQ16629
MouseQ8BL97
Alternative Names
Serine And Arginine Rich Splicing Factor 7; Splicing Factor, Arginine/Serine-Rich 7, 35kDa; Serine/Arginine-Rich Splicing Factor 7; SR Splicing Factor 7; Splicing Factor 9G8; SFRS7;
Function
Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.
Biological Process
Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process mRNA processingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process negative regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA splicingManual Assertion Based On ExperimentIDA:ProtInc
Cellular Location
Nucleus
Cytoplasm
PTM
Extensively phosphorylated on serine residues in the RS domain.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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