Recombinant Mouse Anti-SRSF7 Recombinant Antibody (2G8-1C6) (CBMAB-XB1068-YC)

Name: Recombinant Mouse Anti-SRSF7 Recombinant Antibody (2G8-1C6)
SKU: CBMAB-XB1068-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

2G8-1C6

Application

IF, WB

Immunogen

MSRYGRYGGETK(C)

Specificity

Human, Mouse

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Serine And Arginine Rich Splicing Factor 7

Introduction

SRSF7 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation.

Entrez Gene ID

Human	6432
Mouse	225027

UniProt ID

Human	Q16629
Mouse	Q8BL97

Alternative Names

Serine And Arginine Rich Splicing Factor 7; Splicing Factor, Arginine/Serine-Rich 7, 35kDa; Serine/Arginine-Rich Splicing Factor 7; SR Splicing Factor 7; Splicing Factor 9G8; SFRS7;

Function

Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.

Biological Process

Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process mRNA processingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process negative regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA splicingManual Assertion Based On ExperimentIDA:ProtInc

Cellular Location

Nucleus
Cytoplasm

PTM

Extensively phosphorylated on serine residues in the RS domain.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-SRSF7 Recombinant Antibody (CBLQS-003) (CAT#: CBMAB-2072CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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