Mouse Anti-SSTR2 Recombinant Antibody (CBXS-3435) (CBMAB-S6166-CQ)

Name: Mouse Anti-SSTR2 Recombinant Antibody (CBXS-3435)
SKU: CBMAB-S6166-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-3435

Application

FC, ICC, IHC

Immunogen

NS0 cells transfected with Met1-Ile369 from human Somatostatin Receptor Type 2 (SSTr2) (P30874)

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Somatostatin Receptor 2

Introduction

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.

Entrez Gene ID

6752

UniProt ID

P30874

Alternative Names

Somatostatin Receptor 2; SRIF-1; SS2R; Somatostatin Receptor Type 2; SS-2-R; SS2-R;

Function

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Biological Process

Biological Process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process cellular response to estradiol stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to glucocorticoid stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cerebellum developmentIEA:Ensembl
Biological Process forebrain developmentIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process peristalsisIEA:Ensembl
Biological Process regulation of muscle contractionIEA:Ensembl
Biological Process response to starvationIEA:Ensembl
Biological Process spermatogenesisIEA:Ensembl

Cellular Location

Cell membrane ; Multi-pass membrane protein
Cytoplasm
Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.

Topology

Extracellular: 1-43
Helical: 44-67
Cytoplasmic: 68-78
Helical: 79-103
Extracellular: 104-118
Helical: 119-138
Cytoplasmic: 139-161
Helical: 162-181
Extracellular: 182-207
Helical: 208-229
Cytoplasmic: 230-253
Helical: 254-278
Extracellular: 279-288
Helical: 289-303
Cytoplasmic: 304-369

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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