Mouse Anti-SSX2 Recombinant Antibody (CBXS-4957) (CBMAB-S2179-CQ)

Name: Mouse Anti-SSX2 Recombinant Antibody (CBXS-4957)
SKU: CBMAB-S2179-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-4957

Application

IF, IHC, IHC-P, WB

Immunogen

Protein expressed in 293T cell transfected with human SSX2 expression vector

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SSX Family Member 2

Introduction

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X.

Entrez Gene ID

6757

UniProt ID

Q16385

Alternative Names

SSX Family Member 2; Synovial Sarcoma, X Breakpoint 2; Sarcoma, Synovial, X-Chromosome-Related 2; Cancer/Testis Antigen Family 5, Member 2a; Synovial Sarcoma, X Breakpoint 2B; Cancer/Testis Antigen 5.2; Tumor Antigen HOM-MEL-40; CT5.2; Synovial Sarcoma, X Breakpoint 2, Isoform B;

Function

Could act as a modulator of transcription.

Biological Process

Regulation of DNA-templated transcription

Cellular Location

Nucleus

Involvement in disease

A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

SSX2 Matched Antibody Pair (1144) (CAT#: APMAB-1144LY)

SSX2 Matched Antibody Pair (1145) (CAT#: APMAB-1145LY)

Related Products

Mouse Anti-SSX2 Recombinant Antibody (CBXS-3811) (CAT#: CBMAB-S1082-CQ)

Mouse Anti-SSX2 Recombinant Antibody (1A4) (CAT#: CBMAB-A8619-LY)

Mouse Anti-SSX2 Recombinant Antibody (CBXS-5321) (CAT#: CBMAB-S2535-CQ)

SSX2 Matched Antibody Pair (1144) (CAT#: APMAB-1144LY)

SSX2 Matched Antibody Pair (1145) (CAT#: APMAB-1145LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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