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SSX2

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]

Full Name

SSX Family Member 2

Function

Could act as a modulator of transcription.

Biological Process

Regulation of DNA-templated transcription

Cellular Location

Nucleus

Involvement in disease

A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).

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Anti-SSX2 antibodies

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SSX2 Matched Antibody Pair (1145) (APMAB-1145LY)

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Target: SSX2

Specificity: Human

SSX2 Matched Antibody Pair (1144) (APMAB-1144LY)

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Target: SSX2

Specificity: Human

Mouse Anti-SSX2 Recombinant Antibody (1A4) (CBMAB-A8619-LY)

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Target: SSX2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1A4

Application*: WB, E

Mouse Anti-SSX2 Recombinant Antibody (CBXS-5321) (CBMAB-S2535-CQ)

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Target: SSX2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5321

Application*: IH

Mouse Anti-SSX2 Recombinant Antibody (CBXS-4957) (CBMAB-S2179-CQ)

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Target: SSX2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4957

Application*: IF, IH, P, WB

Mouse Anti-SSX2 Recombinant Antibody (CBXS-3811) (CBMAB-S1082-CQ)

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Target: SSX2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-3811

Application*: E, P, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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