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SSX2

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]
Full Name
SSX Family Member 2
Function
Could act as a modulator of transcription.
Biological Process
Regulation of DNA-templated transcription
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
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Anti-SSX2 antibodies

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SSX2 Matched Antibody Pair (1145) (APMAB-1145LY)

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Target: SSX2
Specificity: Human
Datasheet SDS

SSX2 Matched Antibody Pair (1144) (APMAB-1144LY)

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Target: SSX2
Specificity: Human
Datasheet SDS

Mouse Anti-SSX2 Recombinant Antibody (1A4) (CBMAB-A8619-LY)

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Target: SSX2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1A4
Application*: WB, E
Datasheet SDS

Mouse Anti-SSX2 Recombinant Antibody (CBXS-5321) (CBMAB-S2535-CQ)

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Target: SSX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5321
Application*: IH
Datasheet SDS

Mouse Anti-SSX2 Recombinant Antibody (CBXS-4957) (CBMAB-S2179-CQ)

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Target: SSX2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4957
Application*: IF, IH, P, WB
Datasheet SDS

Mouse Anti-SSX2 Recombinant Antibody (CBXS-3811) (CBMAB-S1082-CQ)

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Target: SSX2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-3811
Application*: E, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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