Mouse Anti-SSX2IP (AA 1-272) Recombinant Antibody (CBXS-3829) (CBMAB-S1099-CQ)

Name: Mouse Anti-SSX2IP (AA 1-272) Recombinant Antibody (CBXS-3829)
SKU: CBMAB-S1099-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBXS-3829

Application

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-272

More Infomation

Target

Full Name

SSX Family Member 2 Interacting Protein

Introduction

This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.

Entrez Gene ID

117178

UniProt ID

Q9Y2D8

Alternative Names

SSX Family Member 2 Interacting Protein; Synovial Sarcoma, X Breakpoint 2 Interacting Protein; Afadin DIL Domain-Interacting Protein; SSX2-Interacting Protein; ADIP; Afadin- And Alpha-Actinin-Binding Protein; KIAA0923; HMsd1;

Function

Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity).
Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity).
Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777).
Involved in ciliogenesis (PubMed:24356449).
It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449).

Biological Process

Biological Process cell adhesionIEA:UniProtKB-KW
Biological Process centrosome cycleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intraciliary transport involved in cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell motilityIEA:Ensembl
Biological Process regulation of Rac protein signal transductionIEA:Ensembl

Cellular Location

Cell junction, adherens junction
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
Cytoplasm, cytoskeleton, cilium basal body
Not found at cell-matrix AJs.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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