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Rabbit Anti-SSX2IP Recombinant Antibody (CBXS-1431) (CBMAB-S4289-CQ)

This product is a rabbit antibody that recognizes SSX2IP. The antibody CBXS-1431 can be used for immunoassay techniques such as: WB, IHC-P, IF.
See all SSX2IP antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1431
Antibody Isotype
IgG
Application
WB, IHC-P, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SSX Family Member 2 Interacting Protein
Introduction
This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.
Entrez Gene ID
Human117178
Mouse99167
Rat308023
UniProt ID
HumanQ9Y2D8
MouseQ8VC66
RatQ8CGZ2
Alternative Names
SSX Family Member 2 Interacting Protein; Synovial Sarcoma, X Breakpoint 2 Interacting Protein; Afadin DIL Domain-Interacting Protein; SSX2-Interacting Protein; ADIP; Afadin- And Alpha-Actinin-Binding Protein; KIAA0923; HMsd1;
Function
Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity).
Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity).
Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777).
Involved in ciliogenesis (PubMed:24356449).
It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449).
Biological Process
Biological Process cell adhesionIEA:UniProtKB-KW
Biological Process centrosome cycleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intraciliary transport involved in cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell motilityIEA:Ensembl
Biological Process regulation of Rac protein signal transductionIEA:Ensembl
Cellular Location
Cell junction, adherens junction
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
Cytoplasm, cytoskeleton, cilium basal body
Not found at cell-matrix AJs.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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