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Mouse Anti-ST6GALNAC5 Recombinant Antibody (CBXS-1902) (CBMAB-S4692-CQ)

This product is a mouse antibody that recognizes ST6GALNAC5. The antibody CBXS-1902 can be used for immunoassay techniques such as: ICC.
See all ST6GALNAC5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1902
Antibody Isotype
IgG2a
Application
ICC

Basic Information

Immunogen
CHO-derived recombinant human SGalNAc alpha-2,6-sialyltransferase V/ST6GALNAC5, Gly30-Phe336, Accession # Q9BVH7
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 5
Introduction
The protein encoded by this gene is a Golgi type II transmembrane glycosyltransferase. The encoded protein catalyzes the transfer of sialic acid to cell surface proteins to modulate cell-cell interactions. Several transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
81849
UniProt ID
Q9BVH7
Alternative Names
SIAT7-E; SIAT7E; ST6GalNAcV
Function
Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b (PubMed:12668675).
GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity).
Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675).
Biological Process
Biological Process ganglioside biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process glycosphingolipid biosynthetic processISS:BHF-UCL
Biological Process oligosaccharide biosynthetic processBy SimilarityISS:BHF-UCL
Biological Process oligosaccharide metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein glycosylationIEA:InterPro
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-8
Helical: 9-29
Lumenal: 30-336
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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