Mouse Anti-ST6GALNAC5 Recombinant Antibody (CBXS-1903) (CBMAB-S4693-CQ)

Name: Mouse Anti-ST6GALNAC5 Recombinant Antibody (CBXS-1903)
SKU: CBMAB-S4693-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBXS-1903

Application

Immunogen

CHO-derived recombinant human GalNAc alpha-2,6-sialyltransferase V/ST6GALNAC5, Gly30-Phe336, Accession # Q9BVH7

Specificity

Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 5

Introduction

The protein encoded by this gene is a Golgi type II transmembrane glycosyltransferase. The encoded protein catalyzes the transfer of sialic acid to cell surface proteins to modulate cell-cell interactions. Several transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

81849

UniProt ID

Q9BVH7

Alternative Names

SIAT7-E; SIAT7E; ST6GalNAcV

Function

Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b (PubMed:12668675).
GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity).
Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675).

Biological Process

Biological Process ganglioside biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process glycosphingolipid biosynthetic processISS:BHF-UCL
Biological Process oligosaccharide biosynthetic processBy SimilarityISS:BHF-UCL
Biological Process oligosaccharide metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein glycosylationIEA:InterPro

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-8
Helical: 9-29
Lumenal: 30-336

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-ST6GALNAC5 Recombinant Antibody (CBXS-1902) (CAT#: CBMAB-S4692-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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