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Mouse Anti-STAC3 Recombinant Antibody (CBXS-2172) (CBMAB-S4935-CQ)

This product is a mouse antibody that recognizes STAC3. The antibody CBXS-2172 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all STAC3 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXS-2172
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SH3 And Cysteine Rich Domain 3
Introduction
The protein encoded by this gene is a component of the excitation-contraction coupling machinery of muscles. This protein is a member of the Stac gene family and contains an N-terminal cysteine-rich domain and two SH3 domains. Mutations in this gene are a cause of Native American myopathy.
Entrez Gene ID
Human246329
Mouse237611
Rat362895
UniProt ID
HumanQ96MF2
MouseQ8BZ71
RatD3ZQN6
Alternative Names
NAM
Function
Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca2+ release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels (PubMed:23736855, PubMed:29078335).
Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (By similarity).
Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:29078335).
Biological Process
Biological Process neuromuscular synaptic transmissionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein localization to plasma membraneISS:UniProtKB
Biological Process positive regulation of voltage-gated calcium channel activityISS:UniProtKB
Biological Process skeletal muscle contractionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process skeletal muscle fiber developmentIEA:Ensembl
Cellular Location
Cytoplasm
Cell membrane, sarcolemma
Cell membrane, sarcolemma, T-tubule
Co-localizes with CACNA1S and CACNA1C on T-tubules.
Involvement in disease
Myopathy, congenital, Bailey-Bloch (MYPBB):
An autosomal recessive disease characterized by congenital weakness and arthrogryposis, cleft palate, ptosis, short stature, kyphoscoliosis, talipes deformities, and susceptibility to malignant hyperthermia provoked by anesthesia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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