Mouse Anti-STAC3 Recombinant Antibody (CBXS-2805) (CBMAB-S5556-CQ)

Name: Mouse Anti-STAC3 Recombinant Antibody (CBXS-2805)
SKU: CBMAB-S5556-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-2805

Application

ELISA, WB

Immunogen

Full length recombinant protein corresponding to aa1-326 from human STAC3 (AAH08069.1) with GST tag

Specificity

Human

Antibody Isotype

IgM, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Ascites fluid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SH3 And Cysteine Rich Domain 3

Introduction

The protein encoded by this gene is a component of the excitation-contraction coupling machinery of muscles. This protein is a member of the Stac gene family and contains an N-terminal cysteine-rich domain and two SH3 domains. Mutations in this gene are a cause of Native American myopathy.

Entrez Gene ID

246329

UniProt ID

Q96MF2

Alternative Names

NAM

Function

Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca2+ release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels (PubMed:23736855, PubMed:29078335).
Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (By similarity).
Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:29078335).

Biological Process

Biological Process neuromuscular synaptic transmissionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein localization to plasma membraneISS:UniProtKB
Biological Process positive regulation of voltage-gated calcium channel activityISS:UniProtKB
Biological Process skeletal muscle contractionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process skeletal muscle fiber developmentIEA:Ensembl

Cellular Location

Cytoplasm
Cell membrane, sarcolemma
Cell membrane, sarcolemma, T-tubule
Co-localizes with CACNA1S and CACNA1C on T-tubules.

Involvement in disease

Myopathy, congenital, Bailey-Bloch (MYPBB):
An autosomal recessive disease characterized by congenital weakness and arthrogryposis, cleft palate, ptosis, short stature, kyphoscoliosis, talipes deformities, and susceptibility to malignant hyperthermia provoked by anesthesia.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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