Mouse Anti-STAP1 Recombinant Antibody (CBXS-3269) (CBMAB-S6009-CQ)

Name: Mouse Anti-STAP1 Recombinant Antibody (CBXS-3269)
SKU: CBMAB-S6009-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBXS-3269

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa186-294 from human BRDG1 (NP_036240) with GST tag

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

STAP1

Introduction

The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

26228

UniProt ID

Q9ULZ2

Alternative Names

BRDG1; STAP-1

Function

In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.

Biological Process

Biological Process cellular response to lipopolysaccharideISS:BHF-UCL
Biological Process negative regulation of macrophage chemotaxisISS:BHF-UCL
Biological Process negative regulation of macrophage colony-stimulating factor signaling pathwayISS:BHF-UCL
Biological Process negative regulation of microglial cell migrationIEA:Ensembl
Biological Process negative regulation of phosphorylationISS:BHF-UCL
Biological Process negative regulation of ruffle assemblyISS:BHF-UCL
Biological Process positive regulation of actin cytoskeleton reorganizationISS:BHF-UCL
Biological Process positive regulation of B cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of gene expressionISS:BHF-UCL
Biological Process positive regulation of microglial cell activationISS:BHF-UCL
Biological Process positive regulation of microglial cell mediated cytotoxicityISS:BHF-UCL
Biological Process positive regulation of phagocytosis, engulfmentISS:BHF-UCL
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayISS:BHF-UCL

Cellular Location

Nucleus
Cytoplasm
Mitochondrion

PTM

Phosphorylated on tyrosine by TEC. Phosphorylated on tyrosine by KIT (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

STAP1 Matched Antibody Pair (1147) (CAT#: APMAB-1147LY)

Related Products

STAP1 Matched Antibody Pair (1147) (CAT#: APMAB-1147LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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