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Mouse Anti-STAP1 Recombinant Antibody (CBXS-3269) (CBMAB-S6009-CQ)

This product is a mouse antibody that recognizes STAP1. The antibody CBXS-3269 can be used for immunoassay techniques such as: ELISA, WB.
See all STAP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3269
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa186-294 from human BRDG1 (NP_036240) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
STAP1
Introduction
The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
26228
UniProt ID
Q9ULZ2
Alternative Names
BRDG1; STAP-1
Function
In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.
Biological Process
Biological Process cellular response to lipopolysaccharideISS:BHF-UCL
Biological Process negative regulation of macrophage chemotaxisISS:BHF-UCL
Biological Process negative regulation of macrophage colony-stimulating factor signaling pathwayISS:BHF-UCL
Biological Process negative regulation of microglial cell migrationIEA:Ensembl
Biological Process negative regulation of phosphorylationISS:BHF-UCL
Biological Process negative regulation of ruffle assemblyISS:BHF-UCL
Biological Process positive regulation of actin cytoskeleton reorganizationISS:BHF-UCL
Biological Process positive regulation of B cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of gene expressionISS:BHF-UCL
Biological Process positive regulation of microglial cell activationISS:BHF-UCL
Biological Process positive regulation of microglial cell mediated cytotoxicityISS:BHF-UCL
Biological Process positive regulation of phagocytosis, engulfmentISS:BHF-UCL
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayISS:BHF-UCL
Cellular Location
Nucleus
Cytoplasm
Mitochondrion
PTM
Phosphorylated on tyrosine by TEC. Phosphorylated on tyrosine by KIT (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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