STAP1

The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants.

Full Name

STAP1

Function

In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.

Biological Process

Biological Process cellular response to lipopolysaccharideISS:BHF-UCL
Biological Process negative regulation of macrophage chemotaxisISS:BHF-UCL
Biological Process negative regulation of macrophage colony-stimulating factor signaling pathwayISS:BHF-UCL
Biological Process negative regulation of microglial cell migrationIEA:Ensembl
Biological Process negative regulation of phosphorylationISS:BHF-UCL
Biological Process negative regulation of ruffle assemblyISS:BHF-UCL
Biological Process positive regulation of actin cytoskeleton reorganizationISS:BHF-UCL
Biological Process positive regulation of B cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of gene expressionISS:BHF-UCL
Biological Process positive regulation of microglial cell activationISS:BHF-UCL
Biological Process positive regulation of microglial cell mediated cytotoxicityISS:BHF-UCL
Biological Process positive regulation of phagocytosis, engulfmentISS:BHF-UCL
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayISS:BHF-UCL

Cellular Location

Nucleus
Cytoplasm
Mitochondrion

PTM

Phosphorylated on tyrosine by TEC. Phosphorylated on tyrosine by KIT (By similarity).