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Rabbit Anti-STAT5A (Phosphorylated Y694) Recombinant Antibody (10E49(D47E7)) (PTM-CBMAB-0008LY)

This antibody is a recombiant antibody against STAT5A. The antibody can be used for immunoassay techniques, such as FC, IF, IP, WB.
See all STAT5A antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
10E49(D47E7)
Antibody Isotype
IgG
Application
FC, IF, IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues surrounding Tyr694 of human Stat5a protein (KLH-coupled)
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Supplied in liquid 10mM HEPES, pH 7.5, 150mM NaCl, 0.1mg/ml BSA, 50% glycerol, 0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
STAT5A
Entrez Gene ID
Human6776
Mouse20850
UniProt ID
HumanP42229
MouseP42230
Function
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
Biological Process
Biological Process cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process defense responseManual Assertion Based On ExperimentIBA:GO_Central
Biological Process growth hormone receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIBA:GO_Central
Biological Process lactationIEA:UniProtKB-KW
Biological Process positive regulation of blood vessel endothelial cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase II1 PublicationIC:ComplexPortal
Biological Process receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIBA:GO_Central
Biological Process reelin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of multicellular organism growthISS:BHF-UCL
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process taurine metabolic processISS:BHF-UCL
Cellular Location
Cytoplasm
Nucleus
Translocated into the nucleus in response to phosphorylation.
PTM
Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (By similarity).
Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus (PubMed:21135090).
Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity).
Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).
Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3 (PubMed:14504097).
Alternatively, can be phosphorylated by JAK2 at Tyr-694 (PubMed:12529425).
ISGylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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