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STAT5A

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq]
Full Name
STAT5A
Function
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
Biological Process
Biological Process cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process defense responseManual Assertion Based On ExperimentIBA:GO_Central
Biological Process growth hormone receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIBA:GO_Central
Biological Process lactationIEA:UniProtKB-KW
Biological Process positive regulation of blood vessel endothelial cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase II1 PublicationIC:ComplexPortal
Biological Process receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIBA:GO_Central
Biological Process reelin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of multicellular organism growthISS:BHF-UCL
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process taurine metabolic processISS:BHF-UCL
Cellular Location
Cytoplasm
Nucleus
Translocated into the nucleus in response to phosphorylation.
PTM
Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (By similarity).
Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus (PubMed:21135090).
Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity).
Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).
Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3 (PubMed:14504097).
Alternatively, can be phosphorylated by JAK2 at Tyr-694 (PubMed:12529425).
ISGylated.

Anti-STAT5A antibodies

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Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXS-6190
Application*: E, IC, IF, P, IP, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse
Clone: M148
Application*: WB, E, IC
Target: STAT5A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-6149
Application*: WB, IP, P, F, IF
Target: STAT5A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBXS-6147
Application*: WB, P
Target: STAT5A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBXS-3524
Application*: F, IC, IH, IP, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3407
Application*: E, F, IH
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBXS-3148
Application*: IP, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXS-3111
Application*: E, IP, WB
Target: STAT5A
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2042
Application*: WB, IP, IF, P, E
Target: STAT5A
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2037
Application*: WB, IP, IF, P, E
Target: STAT5A
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1986
Application*: WB, IC
Target: STAT5A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-0759
Application*: WB, IP, CI
Target: STAT5A
Host: Rabbit
Specificity: Human
Clone: CBXS-0758
Application*: WB, IP, P, IF
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5289
Application*: F, IF, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5144
Application*: WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: CBXS-5096
Application*: P, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5048
Application*: F, IF, P, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3649
Application*: F, P, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-3631
Application*: F, IF, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Dog
Clone: CBXS-5972
Application*: WB, F, IH, IF, P
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5958
Application*: F, IF, P, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5892
Application*: E, WB, P, IF
Target: STAT5A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-5840
Application*: CI, F, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: CBXS-5778
Application*: WB, P, IF
Target: STAT5A
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3565
Application*: F
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1730
Application*: IS
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D4
Application*: E, F, IC, IF, IH, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1B12
Application*: E, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Human, Rat
Clone: 5F6.F1
Application*: E, IC, IF, IH, P, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 251610
Application*: IC
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Mouse
Clone: 251619
Application*: IC, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Dog
Clone: 9F7
Application*: F, IC, IF, IH, P, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 9G11
Application*: E, M
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 7H3
Application*: E, M
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7D8
Application*: E, M
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 4D1
Application*: E, M
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 18G4
Application*: E, M
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 17F6
Application*: E, M
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 11B11
Application*: E, M
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A9
Application*: IP, M
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A11
Application*: IP, M
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4H1
Application*: WB, IP
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 5C10-D3-D10
Application*: WB
Target: STAT5A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-204
Application*: E, WB, IH
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human, Rat
Clone: 9L774
Application*: E, IF, IH, WB
Target: STAT5A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 7H67(C11C5)
Application*: FC, IH, IP, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Cattle, Human, Rat, Sheep
Clone: 6A188
Application*: E, WB
Target: STAT5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B739
Application*: E, FC, IC, IH, WB
Target: STAT5A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 10E49(D47E7)
Application*: FC, IF, IP, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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