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Mouse Anti-STIP1 Recombinant Antibody (2E11) (CBMAB-A8692-LY)

The product is antibody recognizes STIP1. The antibody 2E11 immunoassay techniques such as: WB, ELISA.
See all STIP1 antibodies
Published Data
Fig.1 STIP1 expressed in the cytoplasm of ovarian cancer cells is stained brown.
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Fig.2 Detection of STIP1 on the outer cell membrane of ovarian cancer lines supports its outward transportation.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
2E11
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
STIP1 (NP_006810.1, 445 a.a. ~ 543 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
STIP1
Introduction
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM
Entrez Gene ID
Human10963
Mouse20867
Rat192277
UniProt ID
HumanP31948
MouseQ60864
RatO35814
Alternative Names
HOP; IEF-SSP-3521; P60; STI1; STI1L
Function
Acts as a co-chaperone for HSP90AA1 (PubMed:27353360).
Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).
Biological Process
Biological Process cellular response to interleukin-7IEA:Ensembl
Biological Process protein foldingIEA:InterPro
Cellular Location
Cytoplasm
Nucleus
Dynein axonemal particle
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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