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Mouse Anti-STK26 Recombinant Antibody (CBXS-0962) (CBMAB-S3871-CQ)

This product is a mouse antibody that recognizes STK26. The antibody CBXS-0962 can be used for immunoassay techniques such as: S-ELISA, ELISA, WB, IF.
See all STK26 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBXS-0962
Antibody Isotype
IgG2a, κ
Application
S-ELISA, ELISA, WB, IF

Basic Information

Immunogen
RP6-213H19.1 (NP_057626, 331 a.a.-415 a.a) partial recombinant protein with GST tag
Specificity
Human, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serine/Threonine Kinase 26
Introduction
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Entrez Gene ID
Human51765
Rat317589
UniProt ID
HumanQ9P289
RatF1LXV3
Alternative Names
MASK; MST4
Function
Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971).
Modulates apoptosis (PubMed:11641781, PubMed:17360971).
In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006).
Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556).
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process cellular response to starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process microvillus assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein autophosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of hydrogen peroxide-induced cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to hydrogen peroxideManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Golgi apparatus
Colocalized with RIPOR1 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with RIPOR1 upon serum stimulation in a Rho- and PDCD10-dependent manner (PubMed:27807006).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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