STK26

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Full Name

Serine/Threonine Kinase 26

Function

Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971).
Modulates apoptosis (PubMed:11641781, PubMed:17360971).
In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006).
Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556).

Biological Process

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process cellular response to starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process microvillus assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein autophosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of hydrogen peroxide-induced cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to hydrogen peroxideManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Golgi apparatus
Colocalized with RIPOR1 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with RIPOR1 upon serum stimulation in a Rho- and PDCD10-dependent manner (PubMed:27807006).