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Mouse Anti-STMN2 Recombinant Antibody (CBXS-1888) (CBMAB-S4682-CQ)

This product is a mouse antibody that recognizes STMN2. The antibody CBXS-1888 can be used for immunoassay techniques such as: WB, IHC.
See all STMN2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBXS-1888
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Immunogen
Recombinant human Stathmin-2/STMN2, Tyr26-Gly179, Accession # Q93045
Specificity
Human, Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
stathmin-like 2
Introduction
This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6.
Entrez Gene ID
Human11075
Mouse20257
UniProt ID
HumanQ93045
MouseP55821
Alternative Names
SCG10; SCGN10
Function
Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).
Biological Process
Biological Process cellular response to nerve growth factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process microtubule depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of microtubule depolymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of microtubule polymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of microtubule depolymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Cytoplasm, perinuclear region
Cell projection, growth cone
Membrane
Cell projection, axon
Golgi apparatus
Endosome
Cell projection, lamellipodium
Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity).
Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia.
PTM
Sumoylated.
Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex.
N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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