STMN2

Superior cervical ganglion-10 is a neuronal growth-associated protein that shares significant amino acid sequence similarity with the phosphoprotein stathmin (MIM 151442).[supplied by OMIM
Full Name
stathmin-like 2
Function
Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).
Biological Process
Biological Process cellular response to nerve growth factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process microtubule depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of microtubule depolymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of microtubule polymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of microtubule depolymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Cytoplasm, perinuclear region
Cell projection, growth cone
Membrane
Cell projection, axon
Golgi apparatus
Endosome
Cell projection, lamellipodium
Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity).
Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia.
PTM
Sumoylated.
Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex.
N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.
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Anti-STMN2 antibodies

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Mouse Anti-STMN2 Monoclonal Antibody (MM1103-11G20) (CBMAB-1566-YC)

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Target: STMN2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human, Mouse
Clone: MM1103-11G20
Application*: WB
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (1C6) (CBMAB-A8735-LY)

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Target: STMN2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1C6
Application*: SE, E
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (2E3) (CBMAB-A8734-LY)

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Target: STMN2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E3
Application*: WB, E
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (CBXS-3507) (CBMAB-S6236-CQ)

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Target: STMN2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-3507
Application*: E, WB
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (CBXS-3069) (CBMAB-S5815-CQ)

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Target: STMN2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBXS-3069
Application*: E
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (CBXS-3018) (CBMAB-S5764-CQ)

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Target: STMN2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBXS-3018
Application*: E, WB
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (CBXS-2953) (CBMAB-S5702-CQ)

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Target: STMN2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-2953
Application*: E, WB
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (CBXS-2935) (CBMAB-S5684-CQ)

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Target: STMN2
Host: Mouse
Specificity: Human
Clone: CBXS-2935
Application*: E, WB
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (CBXS-2891) (CBMAB-S5640-CQ)

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Target: STMN2
Host: Mouse
Specificity: Human
Clone: CBXS-2891
Application*: E, WB
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (CBXS-2840) (CBMAB-S5590-CQ)

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Target: STMN2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBXS-2840
Application*: E, WB
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (CBXS-2737) (CBMAB-S5488-CQ)

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Target: STMN2
Host: Mouse
Specificity: Human
Clone: CBXS-2737
Application*: E
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (CBXS-2723) (CBMAB-S5474-CQ)

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Target: STMN2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-2723
Application*: E, WB
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (CBXS-2678) (CBMAB-S5430-CQ)

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Target: STMN2
Host: Mouse
Specificity: Human
Clone: CBXS-2678
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (CBXS-2422) (CBMAB-S5179-CQ)

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Target: STMN2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-2422
Application*: IH, WB
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (CBXS-1888) (CBMAB-S4682-CQ)

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Target: STMN2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBXS-1888
Application*: WB, IH
Datasheet SDS

Rabbit Anti-STMN2 Recombinant Antibody (CBXS-1399) (CBMAB-S4257-CQ)

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Target: STMN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1399
Application*: WB, IP
Datasheet SDS

Rabbit Anti-STMN2 Recombinant Antibody (CBXS-1398) (CBMAB-S4256-CQ)

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Target: STMN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1398
Application*: WB, IP
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (CBXS-0804) (CBMAB-S3731-CQ)

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Target: STMN2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-0804
Application*: SE, E, WB
Datasheet SDS

Mouse Anti-STMN2 Recombinant Antibody (CBXS-0803) (CBMAB-S3730-CQ)

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Target: STMN2
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBXS-0803
Application*: E, WB
Datasheet SDS

Mouse Anti-STMN2 (AA 1-90) Recombinant Antibody (CBXS-0802) (CBMAB-S3729-CQ)

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Target: STMN2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0802
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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