STMN2

Superior cervical ganglion-10 is a neuronal growth-associated protein that shares significant amino acid sequence similarity with the phosphoprotein stathmin (MIM 151442).[supplied by OMIM

stathmin-like 2

Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).

Biological Process cellular response to nerve growth factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process microtubule depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of microtubule depolymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of microtubule polymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of microtubule depolymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasm
Cytoplasm, perinuclear region
Cell projection, growth cone
Membrane
Cell projection, axon
Golgi apparatus
Endosome
Cell projection, lamellipodium
Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity).
Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia.

Sumoylated.
Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex.
N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.