Mouse Anti-STMN2 Recombinant Antibody (2E3) (CBMAB-A8734-LY)

Name: Mouse Anti-STMN2 Recombinant Antibody (2E3)
SKU: CBMAB-A8734-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2E3

Application

WB, ELISA

Immunogen

STMN2 (NP_008960, 1 a.a. ~ 90 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

stathmin-like 2

Introduction

Superior cervical ganglion-10 is a neuronal growth-associated protein that shares significant amino acid sequence similarity with the phosphoprotein stathmin (MIM 151442).[supplied by OMIM

Entrez Gene ID

11075

UniProt ID

Q93045

Alternative Names

SCG10; SCGN10; SGC10

Function

Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).

Biological Process

Biological Process cellular response to nerve growth factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process microtubule depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of microtubule depolymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of microtubule polymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of microtubule depolymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Cytoplasm, perinuclear region
Cell projection, growth cone
Membrane
Cell projection, axon
Golgi apparatus
Endosome
Cell projection, lamellipodium
Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity).
Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia.

PTM

Sumoylated.
Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex.
N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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