Mouse Anti-STXBP2 Recombinant Antibody (CBXS-5625) (CBMAB-S0502-CQ)

Name: Mouse Anti-STXBP2 Recombinant Antibody (CBXS-5625)
SKU: CBMAB-S0502-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-5625

Application

ELISA, IF, IHC, IP, WB

Specificity

Human, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

syntaxin binding protein 2

Introduction

This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Entrez Gene ID

Human	6813
Mouse	20911

UniProt ID

Human	Q15833
Mouse	Q64324

Alternative Names

FHL5; Hunc18b; MUNC18-2; UNC18-2; UNC18B; pp10122

Function

Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.

Biological Process

Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process leukocyte mediated cytotoxicityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process neurotransmitter secretionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neutrophil degranulationManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process regulation of mast cell degranulationISS:UniProtKB
Biological Process vesicle docking involved in exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

azurophil granule
cytolytic granule
cytosol
extracellular exosome
extracellular region
plasma membrane
presynapse
secretory granule
specific granule
tertiary granule

Involvement in disease

Hemophagocytic lymphohistiocytosis, familial, 5, with or without microvillus inclusion disease (FHL5):
A rare, autosomal recessive disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia. Some patients may present in early infancy with severe diarrhea, prior to the onset of typical FHL features, whereas others present later in childhood and have a more protracted course without diarrhea. The early-onset diarrhea is due to enteropathy reminiscent of microvillus inclusion disease.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-STXBP2 Recombinant Antibody (CF416) (CAT#: CBMAB-FT093LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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