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Rabbit Anti-STYX Recombinant Antibody (CBXS-1421) (CBMAB-S4279-CQ)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1421
Antibody Isotype
IgG
Application
WB, IP, FC, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serine/Threonine/Tyrosine Interacting Protein
Introduction
The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes.
Entrez Gene ID
Human6815
Mouse56291
Rat100912536
UniProt ID
HumanQ8WUJ0
MouseQ60969
RatD3ZH31
Alternative Names
Serine/Threonine/Tyrosine Interacting Protein
Function
Catalytically inactive phosphatase (PubMed:23847209).
Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209).
Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209).
By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (PubMed:28007894).
Plays a role in spermatogenesis (By similarity).
Biological Process
Biological Process MAPK export from nucleusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of protein bindingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein dephosphorylationIEA:InterPro
Biological Process regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Cytoplasm, cytosol
Predominantly localizes to the nucleus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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