Rabbit Anti-STYX Recombinant Antibody (CBXS-1421) (CBMAB-S4279-CQ)

Name: Rabbit Anti-STYX Recombinant Antibody (CBXS-1421)
SKU: CBMAB-S4279-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Rabbit

Clone

CBXS-1421

Application

WB, IP, FC, IF

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Serine/Threonine/Tyrosine Interacting Protein

Introduction

The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes.

Entrez Gene ID

Human	6815
Mouse	56291
Rat	100912536

UniProt ID

Human	Q8WUJ0
Mouse	Q60969
Rat	D3ZH31

Alternative Names

Serine/Threonine/Tyrosine Interacting Protein

Function

Catalytically inactive phosphatase (PubMed:23847209).
Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209).
Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209).
By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (PubMed:28007894).
Plays a role in spermatogenesis (By similarity).

Biological Process

Biological Process MAPK export from nucleusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of protein bindingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein dephosphorylationIEA:InterPro
Biological Process regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Cytoplasm, cytosol
Predominantly localizes to the nucleus.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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