STYX

The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes.

Full Name

Serine/Threonine/Tyrosine Interacting Protein

Function

Catalytically inactive phosphatase (PubMed:23847209).
Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209).
Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209).
By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (PubMed:28007894).
Plays a role in spermatogenesis (By similarity).

Biological Process

Biological Process MAPK export from nucleusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of protein bindingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein dephosphorylationIEA:InterPro
Biological Process regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Cytoplasm, cytosol
Predominantly localizes to the nucleus.