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Rabbit Anti-SUDS3 Recombinant Antibody (CBXS-1410) (CBMAB-S4268-CQ)

This product is a rabbit antibody that recognizes SUDS3. The antibody CBXS-1410 can be used for immunoassay techniques such as: WB, FC.
See all SUDS3 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1410
Antibody Isotype
IgG
Application
WB, FC

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1.283 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SDS3 homolog, SIN3A corepressor complex component
Introduction
SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex.
Entrez Gene ID
Human64426
Mouse71954
Rat360819
UniProt ID
HumanQ9H7L9
MouseQ8BR65
RatM0RBT5
Alternative Names
SDS3; SAP45
Function
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process histone deacetylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migration1 PublicationIC:ComplexPortal
Biological Process negative regulation of DNA-templated transcriptionBy SimilarityISS:UniProtKB
Biological Process negative regulation of stem cell population maintenance1 PublicationIC:ComplexPortal
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of transforming growth factor beta receptor signaling pathway1 PublicationIC:ComplexPortal
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of stem cell population maintenance1 PublicationIC:ComplexPortal
Biological Process substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB
Cellular Location
Nucleus
PTM
Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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