Rabbit Anti-SUDS3 Recombinant Antibody (CBXS-1410) (CBMAB-S4268-CQ)

Name: Rabbit Anti-SUDS3 Recombinant Antibody (CBXS-1410)
SKU: CBMAB-S4268-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXS-1410

Application

WB, FC

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1.283 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SDS3 homolog, SIN3A corepressor complex component

Introduction

SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex.

Entrez Gene ID

Human	64426
Mouse	71954
Rat	360819

UniProt ID

Human	Q9H7L9
Mouse	Q8BR65
Rat	M0RBT5

Alternative Names

SDS3; SAP45

Function

Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.

Biological Process

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process histone deacetylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migration1 PublicationIC:ComplexPortal
Biological Process negative regulation of DNA-templated transcriptionBy SimilarityISS:UniProtKB
Biological Process negative regulation of stem cell population maintenance1 PublicationIC:ComplexPortal
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of transforming growth factor beta receptor signaling pathway1 PublicationIC:ComplexPortal
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of stem cell population maintenance1 PublicationIC:ComplexPortal
Biological Process substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB

Cellular Location

Nucleus

PTM

Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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