SUDS3

SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex.

Full Name

SDS3 homolog, SIN3A corepressor complex component

Function

Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.

Biological Process

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process histone deacetylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migration1 PublicationIC:ComplexPortal
Biological Process negative regulation of DNA-templated transcriptionBy SimilarityISS:UniProtKB
Biological Process negative regulation of stem cell population maintenance1 PublicationIC:ComplexPortal
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of transforming growth factor beta receptor signaling pathway1 PublicationIC:ComplexPortal
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of stem cell population maintenance1 PublicationIC:ComplexPortal
Biological Process substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB

Cellular Location

Nucleus

PTM

Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.