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Mouse Anti-SULT2A1 Recombinant Antibody (CBXS-4913) (CBMAB-S2135-CQ)

This product is a mouse antibody that recognizes SULT2A1. The antibody CBXS-4913 can be used for immunoassay techniques such as: FC, WB.
See all SULT2A1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4913
Antibody Isotype
IgG2b
Application
FC, WB

Basic Information

Immunogen
Recombinant full length human SULT2A1 (NP_003158)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SULT2A1
Introduction
Hydroxysteroid sulfotransferase (SULT2A1) is a key enzyme in the testicular and hepatic metabolism of5alpha-androstenone, which is a major component of the off-odor and off-flavorin pork known as boar taint. Sulfotransferase enzymes catalyze the sulfateconjugation of many hormones, neurotransmitters, drugs, and xenobioticcompounds. These cytosolic enzymes are different in their tissue distributionsand substrate specificities. The gene structure (number and length of exons) issimilar among family members. SULT2A1 is a sulfo-conjugating phase II enzymeexpressed at very high levels in the liver and intestine, the two majorfirst-pass metabolic tissues, and in the steroidogenic adrenal tissue. SULT2A1acts preferentially on the hydroxysteroids dehydroepiandrosterone,testosterone/dihydrotestosterone, and pregnenolone and on cholesterol-derivedamphipathic sterol bile acids.
Entrez Gene ID
6822
UniProt ID
Q06520
Alternative Names
HST; ST2; STD; hSTa; DHEAS; ST2A1; ST2A3; DHEA-ST
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed:7678732, PubMed:2268288, PubMed:14573603, PubMed:18042734, PubMed:19589875, PubMed:21187059, PubMed:29671343, PubMed:7854148).
Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis (PubMed:21187059, PubMed:19589875, PubMed:14573603).
Plays a key role in bile acid metabolism (PubMed:2268288).
In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity).
Biological Process
Biological Process 3'-phosphoadenosine 5'-phosphosulfate metabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process bile acid catabolic processIEA:UniProtKB-KW
Biological Process cholesterol metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ethanol catabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process lipid catabolic processIEA:UniProtKB-KW
Biological Process steroid metabolic processManual Assertion Based On ExperimentIDA:GO_Central
Biological Process sulfationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process thyroid hormone metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process xenobiotic metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
PTM
The N-terminus is blocked.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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