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Mouse Anti-SULT2B1 Recombinant Antibody (CBXS-0849) (CBMAB-S3773-CQ)

This product is a mouse antibody that recognizes SULT2B1. The antibody CBXS-0849 can be used for immunoassay techniques such as: S-ELISA, WB, ELISA, WB.
See all SULT2B1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0849
Antibody Isotype
IgG1, κ
Application
S-ELISA, WB, ELISA, WB

Basic Information

Immunogen
SULT2B1 (NP_814444, 1 a.a.-90 a.a) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sulfotransferase family, cytosolic, 2B, member 1
Introduction
Sulfotransferasefamily cytosolic 2B member 1, also known as Sulfotransferase 2B1, ST2B1,Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, SULT2B1 and HSST2,is a cytoplasm protein which belongs to the sulfotransferase 1 family. Thehuman hydroxysteroid sulfotransferase (SULT) family is comprised of twosubfamilies, SULT2A1 and SULT2B1. SULT2B1 is expressed highly in placenta,prostate and trachea. A lesser expression of SULT1B1 was observed in the smallintestine and lung. SULT2B1 catalyzes the sulfate conjugation of many hormones,neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases thewater solubility of most compounds, and therefore their renal excretion, but itcan also result in bioactivation to form active metabolites. SULT2B1 sulfateshydroxysteroids like DHEA. Isoform 1 preferentially sulfonatescholesterol. The two SULT2B1 isoforms, SULT2B1a and SULT2B1b, are encoded by asingle gene as a result of alternative transcription initiation and alternativesplicing. SULT2B1b catalyzes the sulfonation of 3beta-hydroxysteroid hormonesand cholesterol, whereas SULT2B1a preferentially catalyzes pregnenolonesulfonation.
Entrez Gene ID
6820
UniProt ID
O00204
Alternative Names
HSST2
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:19589875, PubMed:12145317).
Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:9799594, PubMed:12145317, PubMed:21855633, PubMed:16855051).
Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633).
Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648).
Isoform 2
Sulfonates pregnenolone but not cholesterol.
Biological Process
Biological Process 3'-phosphoadenosine 5'-phosphosulfate metabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process cholesterol metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of epidermal cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process steroid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sulfationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytosol
Microsome
Nucleus
Phosphorylation of Ser-348 is required for translocation to the nucleus.
Involvement in disease
Ichthyosis, congenital, autosomal recessive 14 (ARCI14):
A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs.
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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