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Mouse Anti-SUZ12 Recombinant Antibody (CBT4186) (V2LY-0625-LY558)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4186
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of human SUZ12 (AA: 1-139) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SUZ12
Entrez Gene ID
23512
Function
Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557).
The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464).
Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557).
Biological Process
Biological Process cell population proliferationIEA:Ensembl
Biological Process dosage compensation by inactivation of X chromosomeIEA:Ensembl
Biological Process histone ubiquitinationIEA:Ensembl
Biological Process negative regulation of cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process oligodendrocyte differentiationIEA:Ensembl
Biological Process positive regulation of cell population proliferationIEA:Ensembl
Cellular Location
Nucleus
Localizes to chromatin as part of the PRC2 complex.
Involvement in disease
Imagawa-Matsumoto syndrome (IMMAS):
An autosomal dominant syndrome characterized by generalized overgrowth, dysmorphic features, musculoskeletal abnormalities, developmental delay and intellectual disability. Some patients have genitourinary and structural brain abnormalities.
PTM
Sumoylated, probably by PIAS2.
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For research use only. Not intended for any clinical use.

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