SUZ12

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.
Full Name
SUZ12
Function
Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557).
The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464).
Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557).
Biological Process
Biological Process cell population proliferationIEA:Ensembl
Biological Process dosage compensation by inactivation of X chromosomeIEA:Ensembl
Biological Process histone ubiquitinationIEA:Ensembl
Biological Process negative regulation of cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process oligodendrocyte differentiationIEA:Ensembl
Biological Process positive regulation of cell population proliferationIEA:Ensembl
Cellular Location
Nucleus
Localizes to chromatin as part of the PRC2 complex.
Involvement in disease
Imagawa-Matsumoto syndrome (IMMAS):
An autosomal dominant syndrome characterized by generalized overgrowth, dysmorphic features, musculoskeletal abnormalities, developmental delay and intellectual disability. Some patients have genitourinary and structural brain abnormalities.
PTM
Sumoylated, probably by PIAS2.
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Anti-SUZ12 antibodies

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Mouse Anti-SUZ12 Recombinant Antibody (SUZ220A) (CBMAB-S6644-CQ)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: SUZ220A
Application*: WB, P, C, F, IF
Datasheet SDS

Rabbit Anti-SUZ12 Recombinant Antibody (
1B10) (V2LY-0725-LY978)

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Target: SUZ12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1B10
Application*: E, WB, IH, IP
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (CBT3113) (V2LY-0625-LY559)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3113
Application*: F
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (CBT4186) (V2LY-0625-LY558)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4186
Application*: WB
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (CBT1172) (V2LY-0625-LY2974)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1172
Application*: WB, P, IF, E
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (CBT1173) (V2LY-0625-LY2973)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1173
Application*: WB, IF, IC, E
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (CBT3530) (V2LY-0625-LY2491)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3530
Application*: IC
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (CBT3879) (V2LY-0625-LY2490)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3879
Application*: IH
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (3D10) (CBMAB-AO999LY)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D10
Application*: WB, IHC
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (2C11) (CBMAB-AO998LY)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C11
Application*: WB, IF
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (2B12-B4-C0) (CBMAB-Z0293-LY)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B12-B4-C0
Application*: WB, IC
Datasheet SDS

Rabbit Anti-SUZ12 Recombinant Antibody (CBXS-6170) (CBMAB-S6386-CQ)

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Target: SUZ12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Horse, Human, Mouse, Pig, Rat
Clone: CBXS-6170
Application*: CI, IF, IP, WB
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (CBXS-3465) (CBMAB-S6196-CQ)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3465
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (CBXS-2479) (CBMAB-S5236-CQ)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2479
Application*: E, WB
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (CBXS-2478) (CBMAB-S5235-CQ)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2478
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (CBXS-1829) (CBMAB-S4635-CQ)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXS-1829
Application*: WB, IP, IC
Datasheet SDS

Rabbit Anti-SUZ12 Recombinant Antibody (CBXS-1526) (CBMAB-S4377-CQ)

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Target: SUZ12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1526
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-SUZ12 (AA 131-305) Recombinant Antibody (CBXS-0883) (CBMAB-S3804-CQ)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0883
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (CBXS-0882) (CBMAB-S3803-CQ)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0882
Application*: E, WB
Datasheet SDS

Rabbit Anti-SUZ12 Recombinant Antibody (CBXS-0881) (CBMAB-S3802-CQ)

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Target: SUZ12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Pig, Horse
Clone: CBXS-0881
Application*: WB, IP, IF, CI
Datasheet SDS

Rabbit Anti-SUZ12 Recombinant Antibody (CBXS-5379) (CBMAB-S2592-CQ)

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Target: SUZ12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Pig, Horse
Clone: CBXS-5379
Application*: WB, IP, IF, CI
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (CBXS-4827) (CBMAB-S2051-CQ)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4827
Application*: IH, WB
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (CBXS-4426) (CBMAB-S1668-CQ)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4426
Application*: IC, IF, WB
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (CBXS-4421) (CBMAB-S1663-CQ)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4421
Application*: E, WB, F
Datasheet SDS

Mouse Anti-SUZ12 Recombinant Antibody (CBXS-5802) (CBMAB-S0659-CQ)

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Target: SUZ12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5802
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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