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Rabbit Anti-SUZ12 Recombinant Antibody (CBXS-0881) (CBMAB-S3802-CQ)

This product is a rabbit antibody that recognizes SUZ12. The antibody CBXS-0881 can be used for immunoassay techniques such as: WB, IP, IF, ChIP.
See all SUZ12 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Pig, Horse
Clone
CBXS-0881
Antibody Isotype
IgG
Application
WB, IP, IF, ChIP

Basic Information

Specificity
Human, Mouse, Rat, Monkey, Pig, Horse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SUZ12
Introduction
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.
Entrez Gene ID
Human23512
Mouse52615
Rat688041
Monkey717834
Pig100294712
Horse100071831
UniProt ID
HumanQ15022
MouseQ80U70
RatA0A0G2JV08
MonkeyF6PUM4
PigF1RKV6
HorseF7DCG7
Alternative Names
CHET9; JJAZ1
Function
Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557).
The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464).
Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557).
Biological Process
Biological Process cell population proliferationIEA:Ensembl
Biological Process dosage compensation by inactivation of X chromosomeIEA:Ensembl
Biological Process histone ubiquitinationIEA:Ensembl
Biological Process negative regulation of cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process oligodendrocyte differentiationIEA:Ensembl
Biological Process positive regulation of cell population proliferationIEA:Ensembl
Cellular Location
Nucleus
Localizes to chromatin as part of the PRC2 complex.
Involvement in disease
Imagawa-Matsumoto syndrome (IMMAS):
An autosomal dominant syndrome characterized by generalized overgrowth, dysmorphic features, musculoskeletal abnormalities, developmental delay and intellectual disability. Some patients have genitourinary and structural brain abnormalities.
PTM
Sumoylated, probably by PIAS2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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