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Mouse Anti-SV2A Recombinant Antibody (CBMAB-0585-LY)

This product is mouse antibody recognizes SV2A of ommata. The antibody immunoassay techniques such as: IF, IP, WB.
See all SV2A antibodies

Summary

Host Animal
Mouse
Specificity
Cattle, Human, Mouse, Rat, Frog, Zebrafish
Antibody Isotype
IgG1
Application
IF, IP, WB

Basic Information

Specificity
Cattle, Human, Mouse, Rat, Frog, Zebrafish
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
synaptic vesicle glycoprotein 2A
Introduction
The protein encoded by this gene is one of three related synaptic vesicle proteins. The encoded protein may interact with synaptotagmin to enhance low frequency neurotransmission in quiescent neurons. Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.
Entrez Gene ID
Human9900
Mouse64051
Rat117559
Zebrafish568033
Frog100379721
Cattle280936
UniProt ID
HumanQ7L0J3
MouseQ9JIS5
RatQ02563
ZebrafishE7F6Z2
FrogF6QL25
CattleQ29397
Function
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).
(Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119).
Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.
Biological Process
Biological Process cellular calcium ion homeostasisIEA:Ensembl
Biological Process regulation of gamma-aminobutyric acid secretionIEA:Ensembl
Biological Process synaptic vesicle primingIEA:Ensembl
Cellular Location
Presynapse
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity).
Colocalizes with ATP2B1 at photoreceptor synaptic terminals.
Topology
Cytoplasmic: 1-169
Helical: 170-190
Extracellular: 191-205
Helical: 206-226
Cytoplasmic: 227-233
Helical: 234-254
Extracellular: 255-262
Helical: 263-283
Cytoplasmic: 284-294
Helical: 295-315
Extracellular: 316-334
Helical: 335-355
Cytoplasmic: 356-447
Helical: 448-468
Extracellular: 469-598
Helical: 599-619
Cytoplasmic: 620-626
Helical: 627-647
Extracellular: 648-651
Helical: 652-672
Cytoplasmic: 673-685
Helical: 686-708
Extracellular: 709-712
Helical: 713-731
Cytoplasmic: 732-742
PTM
Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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