SV2A

The protein encoded by this gene is one of three related synaptic vesicle proteins. The encoded protein may interact with synaptotagmin to enhance low frequency neurotransmission in quiescent neurons. Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.

Full Name

synaptic vesicle glycoprotein 2A

Function

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).
(Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119).
Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.

Biological Process

Biological Process cellular calcium ion homeostasisIEA:Ensembl
Biological Process regulation of gamma-aminobutyric acid secretionIEA:Ensembl
Biological Process synaptic vesicle primingIEA:Ensembl

Cellular Location

Presynapse
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity).
Colocalizes with ATP2B1 at photoreceptor synaptic terminals.

Topology

Cytoplasmic: 1-169
Helical: 170-190
Extracellular: 191-205
Helical: 206-226
Cytoplasmic: 227-233
Helical: 234-254
Extracellular: 255-262
Helical: 263-283
Cytoplasmic: 284-294
Helical: 295-315
Extracellular: 316-334
Helical: 335-355
Cytoplasmic: 356-447
Helical: 448-468
Extracellular: 469-598
Helical: 599-619
Cytoplasmic: 620-626
Helical: 627-647
Extracellular: 648-651
Helical: 652-672
Cytoplasmic: 673-685
Helical: 686-708
Extracellular: 709-712
Helical: 713-731
Cytoplasmic: 732-742

PTM

Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.
N-glycosylated.