Sign in or Register   Sign in or Register
  |  

Mouse Anti-SWAP70 Recombinant Antibody (CBXS-1887) (CBMAB-S4681-CQ)

This product is a mouse antibody that recognizes SWAP70. The antibody CBXS-1887 can be used for immunoassay techniques such as: WB.
See all SWAP70 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBXS-1887
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Recombinant human SWAP70, Arg386-Glu585, Accession # Q9UH65
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SWAP70
Introduction
SWAP70 (Switching B Cell Complex Subunit SWAP70) is a Protein Coding gene. Diseases associated with SWAP70 include Common Variable Immunodeficiency. Among its related pathways are NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is DEF6.Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
Entrez Gene ID
Human23075
Mouse20947
UniProt ID
HumanQ9UH65
MouseQ6A028
Alternative Names
HSPC321; SWAP-70
Function
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
Biological Process
Biological Process actin filament bundle assemblyIEA:Ensembl
Biological Process isotype switchingIEA:Ensembl
Biological Process negative regulation of actin filament depolymerizationIEA:Ensembl
Biological Process negative regulation of cell-cell adhesion mediated by integrinIEA:Ensembl
Biological Process negative regulation of peptidyl-serine dephosphorylationIEA:Ensembl
Biological Process positive regulation of actin filament bundle assemblyIEA:Ensembl
Biological Process positive regulation of cytosolic calcium ion concentrationIEA:Ensembl
Biological Process positive regulation of mast cell chemotaxisIEA:Ensembl
Biological Process regulation of protein localizationIEA:Ensembl
Biological Process regulation of small GTPase mediated signal transductionTAS:Reactome
Cellular Location
Cytoplasm
Cell membrane
Nucleus
Cell projection, lamellipodium
Cytoplasm, cytoskeleton
In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448).
In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448).
Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760).
PTM
Tyrosine-phosphorylated.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SWAP70 Recombinant Antibody (CBXS-1887)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare